[HTML][HTML] Malignant transformation of human cells by constitutive expression of platelet-derived growth factor-BB
B Govindarajan, A Shah, C Cohen, RS Arnold… - Journal of Biological …, 2005 - ASBMB
Platelet-derived growth factors (PDGFs) comprise a family of growth factors strongly
implicated in human oncogenesis. A number of human tumors overexpress PDGF family
members or have translocations activating PDGF receptors. Whereas the epidemiologic
evidence implicating PDGF in human tumors is strong, malignant transformation of human
cells by overexpression of PDGF has not been demonstrated. We have previously
developed a human cell line by the sequential introduction of large T cells and telomerase …
implicated in human oncogenesis. A number of human tumors overexpress PDGF family
members or have translocations activating PDGF receptors. Whereas the epidemiologic
evidence implicating PDGF in human tumors is strong, malignant transformation of human
cells by overexpression of PDGF has not been demonstrated. We have previously
developed a human cell line by the sequential introduction of large T cells and telomerase …