[HTML][HTML] Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors
X Li, M Tjwa, L Moons, P Fons, A Noel… - The Journal of …, 2005 - Am Soc Clin Investig
The Journal of clinical investigation, 2005•Am Soc Clin Investig
The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered
member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report
that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced
differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore,
PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and
stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced …
member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report
that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced
differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore,
PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and
stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced …
The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases.
The Journal of Clinical Investigation