[HTML][HTML] Low-dose IL-2 prevents murine chronic cardiac allograft rejection: Role for IL-2-induced T regulatory cells and exosomes with PD-L1 and CD73
To determine the effects and immunological mechanisms of low-dose interleukin-2 (IL-2) in
a murine model of chronic cardiac allograft rejection (BALB/c to C57BL/6) after costimulatory
blockade consisting of MR1 (250 μg/ip day 0) and CTLA4-Ig (200 μg/ip day 2), we
administered low-dose IL-2 (2000 IU/day) starting on posttransplant day 14 for 3 weeks. T
regulatory (Treg) cell infiltration of the grafts was determined by immunohistochemistry;
circulating exosomes by western blot and aldehyde bead flow cytometry; antibodies to donor …
a murine model of chronic cardiac allograft rejection (BALB/c to C57BL/6) after costimulatory
blockade consisting of MR1 (250 μg/ip day 0) and CTLA4-Ig (200 μg/ip day 2), we
administered low-dose IL-2 (2000 IU/day) starting on posttransplant day 14 for 3 weeks. T
regulatory (Treg) cell infiltration of the grafts was determined by immunohistochemistry;
circulating exosomes by western blot and aldehyde bead flow cytometry; antibodies to donor …