50 years of oral rehydration therapy: the solution is still simple
DR Nalin, RA Cash - The Lancet, 2018 - thelancet.com
DR Nalin, RA Cash
The Lancet, 2018•thelancet.comtime to knockdown or mortality in existing bioassays. Molecular markers of resistance to
these new active ingredients should be identified to help predict the potential for cross-
resistance, as well as contribute to our understanding of how rapidly resistance will spread
and intensify in mosquito populations. These efforts will require more support for
entomological capacity in the field and for national malaria control programmes to gather the
data and advocate for action based on those data. Finally, although the GPIRM is in need of …
these new active ingredients should be identified to help predict the potential for cross-
resistance, as well as contribute to our understanding of how rapidly resistance will spread
and intensify in mosquito populations. These efforts will require more support for
entomological capacity in the field and for national malaria control programmes to gather the
data and advocate for action based on those data. Finally, although the GPIRM is in need of …
time to knockdown or mortality in existing bioassays. Molecular markers of resistance to these new active ingredients should be identified to help predict the potential for cross-resistance, as well as contribute to our understanding of how rapidly resistance will spread and intensify in mosquito populations. These efforts will require more support for entomological capacity in the field and for national malaria control programmes to gather the data and advocate for action based on those data.
Finally, although the GPIRM is in need of updating, its recommendation to use nets with non-pyrethroid active ingredients as soon as they become available is suddenly relevant. They are available now and it is time to use them. However, we must do so judiciously to maintain the efficacy of these new active ingredients and to avoid the crisis we have faced with pyrethroid resistance.
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