[HTML][HTML] Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans
N Hosokawa, Y Kamiya, D Kamiya, K Kato… - Journal of Biological …, 2009 - ASBMB
In the endoplasmic reticulum (ER), lectins and processing enzymes are involved in quality
control of newly synthesized proteins for productive folding as well as in the ER-associated
degradation (ERAD) of misfolded proteins. ER quality control requires the recognition and
modification of the N-linked oligosaccharides attached to glycoproteins. Mannose trimming
from the N-glycans plays an important role in targeting of misfolded glycoproteins for ERAD.
Recently, two mammalian lectins, OS-9 and XTP3-B, which contain mannose 6-phosphate …
control of newly synthesized proteins for productive folding as well as in the ER-associated
degradation (ERAD) of misfolded proteins. ER quality control requires the recognition and
modification of the N-linked oligosaccharides attached to glycoproteins. Mannose trimming
from the N-glycans plays an important role in targeting of misfolded glycoproteins for ERAD.
Recently, two mammalian lectins, OS-9 and XTP3-B, which contain mannose 6-phosphate …