PINCH-1 promotes tubular epithelial-to-mesenchymal transition by interacting with integrin-linked kinase
Y Li, C Dai, C Wu, Y Liu - Journal of the American Society of …, 2007 - journals.lww.com
ABSTRACT PINCH-1 is an adaptor protein that binds to the integrin-linked kinase (ILK), an
intracellular serine/threonine protein kinase that plays a critical role in mediating tubular
epithelial-to-mesenchymal transition (EMT). To determine whether PINCH-1 is also involved
in the EMT process, we investigated its regulation and function during TGF-ß1–stimulated
EMT. TGF-ß1 induced PINCH-1 mRNA and protein expression in human proximal tubular
epithelial cells in a time-dependent fashion, an effect that was largely dependent on …
intracellular serine/threonine protein kinase that plays a critical role in mediating tubular
epithelial-to-mesenchymal transition (EMT). To determine whether PINCH-1 is also involved
in the EMT process, we investigated its regulation and function during TGF-ß1–stimulated
EMT. TGF-ß1 induced PINCH-1 mRNA and protein expression in human proximal tubular
epithelial cells in a time-dependent fashion, an effect that was largely dependent on …
