Keys to the hidden treasures of the mannose 6-phosphate/insulin-like growth factor 2 receptor
AB Hassan - The American journal of pathology, 2003 - ASIP
In 1987, the evidence was published which unequivocally showed that the large mannose 6-
phosphate receptor (275 to 300 kd) was also a receptor for the growth factor, insulin-like
growth factor II (IGF2). 1–3 Since then, investigation of this multifunctional molecule has
continued to reveal interesting information, which extends its relevance across a wide range
of biological and pathological processes, from genomic imprinting, human intelligence, to
tumor suppression. The paper by Wylie et al in this issue of The American Journal of …
phosphate receptor (275 to 300 kd) was also a receptor for the growth factor, insulin-like
growth factor II (IGF2). 1–3 Since then, investigation of this multifunctional molecule has
continued to reveal interesting information, which extends its relevance across a wide range
of biological and pathological processes, from genomic imprinting, human intelligence, to
tumor suppression. The paper by Wylie et al in this issue of The American Journal of …