Transforming growth factor-beta and interleukin-10, but not interleukin-4, down-regulate procoagulant activity and tissue factor expression in human monocyte-derived …
TW Jungi, M Brcic, S Eperon, S Albrecht - Thrombosis research, 1994 - Elsevier
The effect of IL-4, IL-10, and TGF-p on expression of procoagulant activity (PCA) and of
surface-associated tissue factor (TF) by human monocyte-derived macrophages was
determined. Monocytes were allowed to mature to macrophages in teflon bags, and were
primed either in suspension cultures, or after subculturing in microtiter plates. PCA was
determined in PBS-stimulated cells (constitutive PCA) or after stimulation with LPS for 6 hr.
TGF-β significantly reduced constitutive and LPS-induced PCA. This effect was associated …
surface-associated tissue factor (TF) by human monocyte-derived macrophages was
determined. Monocytes were allowed to mature to macrophages in teflon bags, and were
primed either in suspension cultures, or after subculturing in microtiter plates. PCA was
determined in PBS-stimulated cells (constitutive PCA) or after stimulation with LPS for 6 hr.
TGF-β significantly reduced constitutive and LPS-induced PCA. This effect was associated …