MCOLN1/TRPML1 inhibition - a novel strategy used by Helicobacter pylori to escape autophagic killing and antibiotic eradication therapy in vivo
MI Capurro, A Prashar, NL Jones - Autophagy, 2020 - Taylor & Francis
MI Capurro, A Prashar, NL Jones
Autophagy, 2020•Taylor & FrancisInhibition of host macroautophagy/autophagy is one of the strategies used by several
intracellular pathogens, including H. pylori, to escape killing. Here we discuss our recent
work that revealed the novel mechanism by which the vacuolating cytotoxin A (VacA)
produced by H. pylori inhibits lysosomal and autophagic killing. We discovered that VacA
impairs the activity of the lysosomal calcium channel MCOLN1/TRPML1 leading to the
formation of enlarged, dysfunctional lysosomes and autophagosomes that serve as an …
intracellular pathogens, including H. pylori, to escape killing. Here we discuss our recent
work that revealed the novel mechanism by which the vacuolating cytotoxin A (VacA)
produced by H. pylori inhibits lysosomal and autophagic killing. We discovered that VacA
impairs the activity of the lysosomal calcium channel MCOLN1/TRPML1 leading to the
formation of enlarged, dysfunctional lysosomes and autophagosomes that serve as an …
Abstract
Inhibition of host macroautophagy/autophagy is one of the strategies used by several intracellular pathogens, including H. pylori, to escape killing. Here we discuss our recent work that revealed the novel mechanism by which the vacuolating cytotoxin A (VacA) produced by H. pylori inhibits lysosomal and autophagic killing. We discovered that VacA impairs the activity of the lysosomal calcium channel MCOLN1/TRPML1 leading to the formation of enlarged, dysfunctional lysosomes and autophagosomes that serve as an intracellular niche, which allows the bacteria to escape eradication therapy.
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