Accumulation of glyceryl ether lipids in Wolman's disease
HJ Lin, MSLK Jie, FC Ho - Journal of lipid research, 1976 - ASBMB
We have shown that ether-linked glycerolipids accumulated in the adrenal, liver, and spleen
of a male Chinese infant with Wolman's disease; the increases were mainly in the alkyl and
alk-1-enyl glycerolipids that did not contain phosphorus. Alkyldiacylglycerol accounted for a
portion of the rise in the neutral alkylglycerols. The spleen also contained increased
amounts of ether-linked phosphoglycerides of the alkyl and alk-1-enyl types. Organs from a
Niemann-Pick patient were also included in this study; they did not show comparable rises …
of a male Chinese infant with Wolman's disease; the increases were mainly in the alkyl and
alk-1-enyl glycerolipids that did not contain phosphorus. Alkyldiacylglycerol accounted for a
portion of the rise in the neutral alkylglycerols. The spleen also contained increased
amounts of ether-linked phosphoglycerides of the alkyl and alk-1-enyl types. Organs from a
Niemann-Pick patient were also included in this study; they did not show comparable rises …
