[HTML][HTML] Regulation of flagellar motor switching by c-di-GMP phosphodiesterases in Pseudomonas aeruginosa
The second messenger cyclic diguanylate (c-di-GMP) plays a prominent role in regulating
flagellum-dependent motility in the single-flagellated pathogenic bacterium Pseudomonas
aeruginosa. The c-di-GMP–mediated signaling pathways and mechanisms that control
flagellar output remain to be fully unveiled. Studying surface-tethered and free-swimming P.
aeruginosa PAO1 cells, we found that the overexpression of an exogenous diguanylate
cyclase (DGC) raises the global cellular c-di-GMP concentration and thereby inhibits …
flagellum-dependent motility in the single-flagellated pathogenic bacterium Pseudomonas
aeruginosa. The c-di-GMP–mediated signaling pathways and mechanisms that control
flagellar output remain to be fully unveiled. Studying surface-tethered and free-swimming P.
aeruginosa PAO1 cells, we found that the overexpression of an exogenous diguanylate
cyclase (DGC) raises the global cellular c-di-GMP concentration and thereby inhibits …