Inflammation promotes a cytokine response and disrupts the cervical epithelial barrier: a possible mechanism of premature cervical remodeling and preterm birth
C Nold, L Anton, A Brown, M Elovitz - American journal of obstetrics and …, 2012 - Elsevier
OBJECTIVE: An inflammatory challenge disrupts the cervical epithelial barrier and promotes
cervical remodeling. STUDY DESIGN: Immortalized ectocervical and endocervical cells
were treated with lipopolysaccharide (LPS), and interleukin (IL)-6, IL-8, and soluble E-
cadherin (SECAD) were assessed. Cells were then pretreated with dexamethasone prior to
LPS exposure, and IL-6, IL-8, and SECAD levels were again assessed. The integrity of the
epithelial cell barrier was determined using a permeability assay. RESULTS: LPS …
cervical remodeling. STUDY DESIGN: Immortalized ectocervical and endocervical cells
were treated with lipopolysaccharide (LPS), and interleukin (IL)-6, IL-8, and soluble E-
cadherin (SECAD) were assessed. Cells were then pretreated with dexamethasone prior to
LPS exposure, and IL-6, IL-8, and SECAD levels were again assessed. The integrity of the
epithelial cell barrier was determined using a permeability assay. RESULTS: LPS …