Synthesis of fluorine-18 radio-labeled serum albumins for PET blood pool imaging
F Basuli, C Li, B Xu, M Williams, K Wong… - Nuclear medicine and …, 2015 - Elsevier
We sought to develop a practical, reproducible and clinically translatable method of
radiolabeling serum albumins with fluorine-18 for use as a PET blood pool imaging agent in
animals and man. Fluorine-18 radiolabeled fluoronicotinic acid-2, 3, 5, 6-tetrafluorophenyl
ester,[18 F] F-Py-TFP was prepared first by the reaction of its quaternary ammonium triflate
precursor with [18 F] tetrabutylammonium fluoride ([18 F] TBAF) according to a previously
published method for peptides, with minor modifications. The incubation of [18 F] F-Py-TFP …
radiolabeling serum albumins with fluorine-18 for use as a PET blood pool imaging agent in
animals and man. Fluorine-18 radiolabeled fluoronicotinic acid-2, 3, 5, 6-tetrafluorophenyl
ester,[18 F] F-Py-TFP was prepared first by the reaction of its quaternary ammonium triflate
precursor with [18 F] tetrabutylammonium fluoride ([18 F] TBAF) according to a previously
published method for peptides, with minor modifications. The incubation of [18 F] F-Py-TFP …