HPA axis dysregulation in mice overexpressing corticotropin releasing hormone
L Groenink, A Dirks, PM Verdouw, M lutje Schipholt… - Biological …, 2002 - Elsevier
Background: Hypersecretion of corticotropin-releasing hormone (CRH) in the brain has
been implicated in stress-related human pathologies. We developed a transgenic mouse
line overexpressing CRH (CRH-OE) exclusively in neural tissues to assess the effect of long-
term CRH overproduction on regulation of the hypothalamic-pituitary-adrenal (HPA) axis.
Methods: Male transgenic CRH-OE2122 mice on a C57BL/6J background were used.
Littermate wildtype mice served as control animals. Basal plasma corticotropin and …
been implicated in stress-related human pathologies. We developed a transgenic mouse
line overexpressing CRH (CRH-OE) exclusively in neural tissues to assess the effect of long-
term CRH overproduction on regulation of the hypothalamic-pituitary-adrenal (HPA) axis.
Methods: Male transgenic CRH-OE2122 mice on a C57BL/6J background were used.
Littermate wildtype mice served as control animals. Basal plasma corticotropin and …