Cerebrospinal fluid cytokines in patients with tuberculous meningitis
The levels of tumor necrosis factor (TNF)-α, soluble TNF receptors p75 (sTNFR-75) and
sTNFR-55, interferon (IFN)-γ, and interleukin (IL)-10 and IL-12 were measured in 59
cerebrospinal fluid (CSF) samples from 15 patients with tuberculous meningitis (TBM). TBM
was associated with elevated concentrations of TNF-α, sTNFR-75, sTNFR-55, IFN-γ, and IL-
10, while CSF IL-12 was undetectable in all TBM patients. A significant correlation between
cytokines and CSF adenosine deaminase activity was also found. The levels of TNF-α did …
sTNFR-55, interferon (IFN)-γ, and interleukin (IL)-10 and IL-12 were measured in 59
cerebrospinal fluid (CSF) samples from 15 patients with tuberculous meningitis (TBM). TBM
was associated with elevated concentrations of TNF-α, sTNFR-75, sTNFR-55, IFN-γ, and IL-
10, while CSF IL-12 was undetectable in all TBM patients. A significant correlation between
cytokines and CSF adenosine deaminase activity was also found. The levels of TNF-α did …