ZAP-70: an essential kinase in T-cell signaling
H Wang, TA Kadlecek… - Cold Spring …, 2010 - cshperspectives.cshlp.org
Cold Spring Harbor perspectives in biology, 2010•cshperspectives.cshlp.org
ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events
involved in initiating T-cell responses by the antigen receptor. Here we review the structure
of ZAP-70, its regulation, its role in development and in disease. We also describe a model
experimental system in which ZAP-70 function can be interrupted by a small chemical
inhibitor.
involved in initiating T-cell responses by the antigen receptor. Here we review the structure
of ZAP-70, its regulation, its role in development and in disease. We also describe a model
experimental system in which ZAP-70 function can be interrupted by a small chemical
inhibitor.
ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its regulation, its role in development and in disease. We also describe a model experimental system in which ZAP-70 function can be interrupted by a small chemical inhibitor.
cshperspectives.cshlp.org