[HTML][HTML] Interleukin-1 in the response of follicular helper and follicular regulatory T cells
PG Ritvo, D Klatzmann - Frontiers in immunology, 2019 - frontiersin.org
PG Ritvo, D Klatzmann
Frontiers in immunology, 2019•frontiersin.orgThe role of interleukin-1 in the regulation of humoral responses is poorly documented, in
contrast to its role in inflammation. Recent findings suggest there is an interleukin-1 axis in
the follicular T cell control of B cell responses, involving interleukin-1 receptors (IL-1R1 and
IL-1R2) and receptor antagonists (IL-1Ra). Here, we revisit the literature on this topic and
conclude that targeting the interleukin-1 pathway should be a valuable therapeutic approach
in many diseases involving excessive production of (auto) antibodies, such as autoimmune …
contrast to its role in inflammation. Recent findings suggest there is an interleukin-1 axis in
the follicular T cell control of B cell responses, involving interleukin-1 receptors (IL-1R1 and
IL-1R2) and receptor antagonists (IL-1Ra). Here, we revisit the literature on this topic and
conclude that targeting the interleukin-1 pathway should be a valuable therapeutic approach
in many diseases involving excessive production of (auto) antibodies, such as autoimmune …
The role of interleukin-1 in the regulation of humoral responses is poorly documented, in contrast to its role in inflammation. Recent findings suggest there is an interleukin-1 axis in the follicular T cell control of B cell responses, involving interleukin-1 receptors (IL-1R1 and IL-1R2) and receptor antagonists (IL-1Ra). Here, we revisit the literature on this topic and conclude that targeting the interleukin-1 pathway should be a valuable therapeutic approach in many diseases involving excessive production of (auto)antibodies, such as autoimmune diseases or allergy.
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