HAIR-AN syndrome (hyperandrogenism, insulin resistance, acanthosis nigricans) is a
subset of the polycystic ovary syndrome, where the patients demonstrate severe insulin
resistance. It is theorized that both genetic and environmental factors, such as obesity, give
rise to the development of HAIR-AN. Diagnosis is primarily clinical, with laboratory values
lending further support. Treatment is aimed at decreasing insulin resistance, regulating
ovulation, and decreasing acne, acanthosis nigricans, and hirsutism.