Connecting mTORC1 signaling to SREBP-1 activation
I Bakan, M Laplante - Current opinion in lipidology, 2012 - journals.lww.com
I Bakan, M Laplante
Current opinion in lipidology, 2012•journals.lww.comThe discovery of a connection between mTORC1 and SREBP-1 opens a new chapter in our
understanding of the molecular mechanisms regulating de-novo lipogenesis. A better
comprehension of these mechanisms is key for the development of new tools to treat NAFLD
and its complications.
understanding of the molecular mechanisms regulating de-novo lipogenesis. A better
comprehension of these mechanisms is key for the development of new tools to treat NAFLD
and its complications.
Summary
The discovery of a connection between mTORC1 and SREBP-1 opens a new chapter in our understanding of the molecular mechanisms regulating de-novo lipogenesis. A better comprehension of these mechanisms is key for the development of new tools to treat NAFLD and its complications.
Lippincott Williams & Wilkins