[HTML][HTML] The evolving role of neutrophils in liver transplant ischemia-reperfusion injury
K Nakamura, S Kageyama… - Current transplantation …, 2019 - Springer
K Nakamura, S Kageyama, JW Kupiec-Weglinski
Current transplantation reports, 2019•SpringerAbstract Purpose of Review Hepatic ischemia-reperfusion injury (IRI), an inevitable event
during liver transplantation, represents a major risk factor for the primary graft dysfunction as
well as the development of acute and chronic rejection. Neutrophils, along macrophages,
are pivotal in the innate immune-driven liver IRI, whereas the effective neutrophil-targeting
therapies remain to be established. In this review, we summarize progress in our
appreciation of the neutrophil biology and discuss neutrophil-based therapeutic …
during liver transplantation, represents a major risk factor for the primary graft dysfunction as
well as the development of acute and chronic rejection. Neutrophils, along macrophages,
are pivotal in the innate immune-driven liver IRI, whereas the effective neutrophil-targeting
therapies remain to be established. In this review, we summarize progress in our
appreciation of the neutrophil biology and discuss neutrophil-based therapeutic …
Purpose of Review
Hepatic ischemia-reperfusion injury (IRI), an inevitable event during liver transplantation, represents a major risk factor for the primary graft dysfunction as well as the development of acute and chronic rejection. Neutrophils, along macrophages, are pivotal in the innate immune-driven liver IRI, whereas the effective neutrophil-targeting therapies remain to be established. In this review, we summarize progress in our appreciation of the neutrophil biology and discuss neutrophil-based therapeutic perspectives.
Recent Findings
New technological advances enable to accurately track neutrophil movements and help to understand molecular mechanisms in neutrophil function, such as selective recruitment to IR-stressed tissue, formation of neutrophil extracellular traps, or reverse migration into circulation. In addition to pro-inflammatory and tissue-destructive functions, immune regulatory and tissue-repairing phenotype associated with distinct neutrophil subsets have been identified.
Summary
Newly recognized and therapeutically attractive neutrophil characteristics warrant comprehensive preclinical and clinical attention to target IRI in transplant recipients.
Springer