Tolerance induction in HLA disparate living donor kidney transplantation by facilitating cell-enriched donor stem cell Infusion: the importance of durable chimerism
JR Leventhal, ST Ildstad - Human Immunology, 2018 - Elsevier
Successful solid organ transplantation currently requires the life-long use of medications to
suppress the immune system in order to prevent transplant rejection. Drug-based
immunosuppression significantly increases the risk of infection and cancer, as well as being
very costly. Development of new therapies to minimize or eliminate entirely the need for anti-
rejection drugs is of great interest to the transplant community. Therapeutic cell transfer for
the control of the human immune system represents a compelling approach to reduce or …
suppress the immune system in order to prevent transplant rejection. Drug-based
immunosuppression significantly increases the risk of infection and cancer, as well as being
very costly. Development of new therapies to minimize or eliminate entirely the need for anti-
rejection drugs is of great interest to the transplant community. Therapeutic cell transfer for
the control of the human immune system represents a compelling approach to reduce or …