[HTML][HTML] Application of operational tolerance signatures are limited by variability and type of immunosuppression in renal transplant recipients: a cross-sectional study
MJ Bottomley, M Chen, S Fuggle, PN Harden… - Transplantation …, 2017 - journals.lww.com
Background Renal transplant recipients (RTR) frequently develop complications relating to
chronic immunosuppression. Identifying RTR who could safely reduce immunosuppression
is therefore highly desirable. We hypothesized that “signatures” described in RTR who have
stopped immunosuppression but maintained stable graft function (“operational tolerance”)
may enable identification of immunosuppressed RTR who are candidates for
immunosuppression minimization. However, the effect of immunosuppression itself on these …
chronic immunosuppression. Identifying RTR who could safely reduce immunosuppression
is therefore highly desirable. We hypothesized that “signatures” described in RTR who have
stopped immunosuppression but maintained stable graft function (“operational tolerance”)
may enable identification of immunosuppressed RTR who are candidates for
immunosuppression minimization. However, the effect of immunosuppression itself on these …