A 2-hit model for chronic GVHD
R Parkman - Blood, The Journal of the American Society of …, 2013 - ashpublications.org
R Parkman
Blood, The Journal of the American Society of Hematology, 2013•ashpublications.orgIn this issue of Blood, Dertschnig and colleagues1 demonstrate in mice that acute graft-
versus-host disease (GHVD) results in a marked reduction of autoimmune receptor–
expressing medullary thymic epithelial cells (Aire 1 mTEC) and a decrease in the diversity of
Aire-dependent tissue-restricted peripheral selfantigens (TRAs) required for effective
negative thymic selection. Both of these abnormalities are reversed by the peritransplant
administration of the epithelial protectant drug, fibroblast growth factor 7 (Fgf7).
versus-host disease (GHVD) results in a marked reduction of autoimmune receptor–
expressing medullary thymic epithelial cells (Aire 1 mTEC) and a decrease in the diversity of
Aire-dependent tissue-restricted peripheral selfantigens (TRAs) required for effective
negative thymic selection. Both of these abnormalities are reversed by the peritransplant
administration of the epithelial protectant drug, fibroblast growth factor 7 (Fgf7).
In this issue of Blood, Dertschnig and colleagues1 demonstrate in mice that acute graft-versus-host disease (GHVD) results in a marked reduction of autoimmune receptor–expressing medullary thymic epithelial cells (Aire 1 mTEC) and a decrease in the diversity of Aire-dependent tissue-restricted peripheral selfantigens (TRAs) required for effective negative thymic selection. Both of these abnormalities are reversed by the peritransplant administration of the epithelial protectant drug, fibroblast growth factor 7 (Fgf7).
ashpublications.org