[HTML][HTML] Therapeutic potential of fibroblast growth factor-2 for hypertrophic scars: upregulation of MMP-1 and HGF expression
H Eto, H Suga, N Aoi, H Kato, K Doi, S Kuno… - Laboratory …, 2012 - Elsevier
Although hypertrophic scars (HTSs) and keloids are challenging problems, their
pathogenesis is not well understood, making therapy difficult. We showed that matrix
metalloproteinase (MMP)-1 expression was downregulated in HTS compared with normal
skin from the same patients, whereas type 1 and 3 collagen and transforming growth factor-β
(TGF-β) were upregulated. These differences, however, were not seen in cultured
fibroblasts, suggesting the involvement of microenvironmental factors in the pathogenesis of …
pathogenesis is not well understood, making therapy difficult. We showed that matrix
metalloproteinase (MMP)-1 expression was downregulated in HTS compared with normal
skin from the same patients, whereas type 1 and 3 collagen and transforming growth factor-β
(TGF-β) were upregulated. These differences, however, were not seen in cultured
fibroblasts, suggesting the involvement of microenvironmental factors in the pathogenesis of …
