IL233, a novel IL-2 and IL-33 hybrid cytokine, ameliorates renal injury
Abstract CD4+ Foxp3+ regulatory T cells (Tregs) protect the kidney during AKI. We
previously found that IL-2, which is critical for Treg homeostasis, upregulates the IL-33
receptor (ST2) on CD4+ T cells, thus we hypothesized that IL-2 and IL-33 cooperate to
enhance Treg function. We found that a major subset of Tregs in mice express ST2, and
coinjection of IL-2 and IL-33 increased the number of Tregs in lymphoid organs and
protected mice from ischemia-reperfusion injury (IRI) more efficiently than either cytokine …
previously found that IL-2, which is critical for Treg homeostasis, upregulates the IL-33
receptor (ST2) on CD4+ T cells, thus we hypothesized that IL-2 and IL-33 cooperate to
enhance Treg function. We found that a major subset of Tregs in mice express ST2, and
coinjection of IL-2 and IL-33 increased the number of Tregs in lymphoid organs and
protected mice from ischemia-reperfusion injury (IRI) more efficiently than either cytokine …
