Specific IgG4 antibodies to cow's milk proteins in pediatric patients with eosinophilic esophagitis

AJ Schuyler, JM Wilson, A Tripathi, SP Commins… - Journal of Allergy and …, 2018 - Elsevier
Background Allergen-specific IgG 4 (sIgG 4) antibodies are often associated with tolerance,
but sIgG 4 antibodies to causally relevant foods have been reported recently in adults with
eosinophilic esophagitis (EoE). Prevalence and levels of food sIgG 4 are not well
established in the general pediatric population. Objective We sought to investigate serum
food sIgG 4 with component diagnostics in children with EoE and children from an
unselected birth cohort and to explore the effects of sex, age, and milk consumption on sIgG …