Mast cells produce interleukin-25 upon FcεRI-mediated activation
K Ikeda, H Nakajima, K Suzuki… - Blood, The Journal …, 2003 - ashpublications.org
K Ikeda, H Nakajima, K Suzuki, S Kagami, K Hirose, A Suto, Y Saito, I Iwamoto
Blood, The Journal of the American Society of Hematology, 2003•ashpublications.orgInterleukin-25 (IL-25) is a recently described T helper 2 (TH2) cell–derived cytokine that
belongs to the IL-17 family and induces the production of IL-4, IL-5, and IL-13 from an
unidentified non–T-cell population. Here, we show that mast cells are also potent IL-25–
producing cells. When bone marrow–derived mast cells were stimulated by immunoglobulin
E cross-linking, IL-25 mRNA was induced within 30 minutes in a calcineurin-dependent
manner, and the levels of IL-25 mRNA were comparable with those of activated TH2 cells …
belongs to the IL-17 family and induces the production of IL-4, IL-5, and IL-13 from an
unidentified non–T-cell population. Here, we show that mast cells are also potent IL-25–
producing cells. When bone marrow–derived mast cells were stimulated by immunoglobulin
E cross-linking, IL-25 mRNA was induced within 30 minutes in a calcineurin-dependent
manner, and the levels of IL-25 mRNA were comparable with those of activated TH2 cells …
Interleukin-25 (IL-25) is a recently described T helper 2 (TH2) cell–derived cytokine that belongs to the IL-17 family and induces the production of IL-4, IL-5, and IL-13 from an unidentified non–T-cell population. Here, we show that mast cells are also potent IL-25–producing cells. When bone marrow–derived mast cells were stimulated by immunoglobulin E cross-linking, IL-25 mRNA was induced within 30 minutes in a calcineurin-dependent manner, and the levels of IL-25 mRNA were comparable with those of activated TH2 cells. Production of IL-25 by mast cells was also detected at protein levels by immunoblotting. These results suggest that mast cells may enhance TH2-type immune response by producing IL-25.
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