[HTML][HTML] Endothelial Jagged1 promotes solid tumor growth through both pro-angiogenic and angiocrine functions
AR Pedrosa, A Trindade, C Carvalho, J Graça… - Oncotarget, 2015 - ncbi.nlm.nih.gov
AR Pedrosa, A Trindade, C Carvalho, J Graça, S Carvalho, MC Peleteiro, RH Adams…
Oncotarget, 2015•ncbi.nlm.nih.govAngiogenesis is an essential process required for tumor growth and progression. The Notch
signaling pathway has been identified as a key regulator of the neo-angiogenic process.
Jagged-1 (Jag1) is a Notch ligand required for embryonic and retinal vascular development,
which direct contribution to the regulation of tumor angiogenesis remains to be fully
characterized.
signaling pathway has been identified as a key regulator of the neo-angiogenic process.
Jagged-1 (Jag1) is a Notch ligand required for embryonic and retinal vascular development,
which direct contribution to the regulation of tumor angiogenesis remains to be fully
characterized.
Abstract
Angiogenesis is an essential process required for tumor growth and progression. The Notch signaling pathway has been identified as a key regulator of the neo-angiogenic process. Jagged-1 (Jag1) is a Notch ligand required for embryonic and retinal vascular development, which direct contribution to the regulation of tumor angiogenesis remains to be fully characterized.
ncbi.nlm.nih.gov
