Decreased expression of myotonic dystrophy protein kinase and disorganization of sarcoplasmic reticulum in skeletal muscle of myotonic dystrophy
H Ueda, M Shimokawa, M Yamamoto… - Journal of the …, 1999 - Elsevier
Pathological expression of myotonic dystrophy protein kinase (DMPK) in skeletal muscle of
myotonic dystrophy (DM) was studied by Western blot analysis, immunohistochemistry, and
immunoelectron microscopy of DMPK. Western blot analysis showed that DMPK protein in
DM skeletal muscles dramatically decreased. DMPK-positive muscle fibers showed typical
DM pathological changes such as type I atrophy, central nuclei, nuclear chains, and
sarcoplasmic masses. In degenerated DMPK-positive muscle fibers, cross-striated bands …
myotonic dystrophy (DM) was studied by Western blot analysis, immunohistochemistry, and
immunoelectron microscopy of DMPK. Western blot analysis showed that DMPK protein in
DM skeletal muscles dramatically decreased. DMPK-positive muscle fibers showed typical
DM pathological changes such as type I atrophy, central nuclei, nuclear chains, and
sarcoplasmic masses. In degenerated DMPK-positive muscle fibers, cross-striated bands …