[HTML][HTML] Activation and repression of cellular immediate early genes by serum response factor cofactors
SM Lee, M Vasishtha, R Prywes - Journal of biological chemistry, 2010 - ASBMB
The induction of expression of many cellular immediate early genes (IEG) involves the
transcription factor serum response factor (SRF). Two families of SRF coactivators have also
been implicated in IEG induction, the ternary complex factors (TCFs), ELK1, Sap1, and Net,
and the myocardin-related factors, MKL1 and MKL2. We found that serum induction of some
SRF target genes is preferentially regulated by MKL1/2, whereas others are redundantly
activated by both TCFs and MKL1/2. Yet ELK1 can also repress transcription. Binding of …
transcription factor serum response factor (SRF). Two families of SRF coactivators have also
been implicated in IEG induction, the ternary complex factors (TCFs), ELK1, Sap1, and Net,
and the myocardin-related factors, MKL1 and MKL2. We found that serum induction of some
SRF target genes is preferentially regulated by MKL1/2, whereas others are redundantly
activated by both TCFs and MKL1/2. Yet ELK1 can also repress transcription. Binding of …