[HTML][HTML] Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells
M Zhang, M Robitaille, AD Showalter, X Huang… - Molecular & cellular …, 2014 - ASBMB
Glucagon-like peptide-1 (GLP-1) is an incretin hormone that regulates glucose homeostasis.
Because of their direct stimulation of insulin secretion from pancreatic β cells, GLP-1
receptor (GLP-1R) agonists are now important therapeutic options for the treatment of type 2
diabetes. To better understand the mechanisms that control the insulinotropic actions of GLP-
1, affinity purification and mass spectrometry (AP-MS) were employed to uncover potential
proteins that functionally interact with the GLP-1R. AP-MS performed on Chinese hamster …
Because of their direct stimulation of insulin secretion from pancreatic β cells, GLP-1
receptor (GLP-1R) agonists are now important therapeutic options for the treatment of type 2
diabetes. To better understand the mechanisms that control the insulinotropic actions of GLP-
1, affinity purification and mass spectrometry (AP-MS) were employed to uncover potential
proteins that functionally interact with the GLP-1R. AP-MS performed on Chinese hamster …
