Lymphangioleiomyomatosis (LAM) is a rare disease found primarily in white women of
childbearing age. The present study describes a case of recurrent LAM after single lung
transplantation. Double-staining nonisotopic in situ hybridization, immunohistochemistry,
and short tandem repeat loci analysis demonstrated that the recurrent LAM lesions
originated from the recipient. The data strongly support that metastatic spread of LAM cells
or migration of progenitor cells plays an important role in the pathogenesis of LAM. HUM …