Macrophages in chronic type 2 inflammation have a novel phenotype characterized by the abundant expression of Ym1 and Fizz1 that can be partly replicated in vitro
MG Nair, DW Cochrane, JE Allen - Immunology letters, 2003 - Elsevier
Using a murine model of nematode infection, we have discovered macrophages that display
a novel phenotype that may be characteristic of macrophages in chronic type 2
inflammation. These nematode-elicited macrophages (NeMφ) are characterized by two
unique features: the ability to actively suppress proliferation of a broad range of cell types
and the high level expression of two novel macrophage genes, Ym1 and Fizz1. NeMφ also
show some similarities with in vitro-derived 'alternatively activated macrophages' such as the …
a novel phenotype that may be characteristic of macrophages in chronic type 2
inflammation. These nematode-elicited macrophages (NeMφ) are characterized by two
unique features: the ability to actively suppress proliferation of a broad range of cell types
and the high level expression of two novel macrophage genes, Ym1 and Fizz1. NeMφ also
show some similarities with in vitro-derived 'alternatively activated macrophages' such as the …