Latent Mycobacterium tuberculosis–persistence, patience, and winning by waiting
YC Manabe, WR Bishai - Nature medicine, 2000 - nature.com
YC Manabe, WR Bishai
Nature medicine, 2000•nature.comMycobacterium tuberculosis is a globally successful pathogen due to its ability to persist for
long periods of time unrecognized by the human immune system. The panoply of genes that
allows the organism to enter latency and then re-emerge later during endogenous
reinfection are now being elucidated. Novel antimicrobials and vaccines will need to target
these mycobacterial pathogenic mechanisms to suceed against tuberculosis.
long periods of time unrecognized by the human immune system. The panoply of genes that
allows the organism to enter latency and then re-emerge later during endogenous
reinfection are now being elucidated. Novel antimicrobials and vaccines will need to target
these mycobacterial pathogenic mechanisms to suceed against tuberculosis.
Abstract
Mycobacterium tuberculosis is a globally successful pathogen due to its ability to persist for long periods of time unrecognized by the human immune system. The panoply of genes that allows the organism to enter latency and then re-emerge later during endogenous reinfection are now being elucidated. Novel antimicrobials and vaccines will need to target these mycobacterial pathogenic mechanisms to suceed against tuberculosis.
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