[HTML][HTML] Clonal evolution in marrows of patients with Shwachman-Diamond syndrome: a prospective 5-year follow-up study
Y Dror, P Durie, H Ginzberg, R Herman… - Experimental …, 2002 - Elsevier
OBJECTIVES: Shwachman-Diamond syndrome (SDS) is characterized by varying degrees
of marrow failure. Retrospective studies suggested a high propensity for malignant myeloid
transformation into myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML).
The study's aims were to determine the cellular and molecular characteristics as well as the
clinical course of malignant myeloid transformation and clonal marrow disease in patients
with SDS. METHODS: This is a longitudinal prospective study of 14 patients recruited for …
of marrow failure. Retrospective studies suggested a high propensity for malignant myeloid
transformation into myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML).
The study's aims were to determine the cellular and molecular characteristics as well as the
clinical course of malignant myeloid transformation and clonal marrow disease in patients
with SDS. METHODS: This is a longitudinal prospective study of 14 patients recruited for …
