In vivo protection against NMDA-induced neurodegeneration by MK-801 and nimodipine: combined therapy and temporal course of protection
BT Stuiver, BRK Douma, R Bakker, C Nyakas… - …, 1996 - Elsevier
Neuroprotection against excitotoxicity by a combined therapy with the N-methyl-D-aspartate
(NMDA) receptor antagonist MK-801 and the L-type Ca2+ channel blocker nimodipine was
examined using an in vivo rat model of NMDA-induced neurodegeneration. Attention was
focused on the neuroprotective potential of this combined drug
treatmentbeforeandafterNMDA-exposure. NMDA was unilaterally injected in the
magnocellular nucleus basalis (MBN). Neuronal damage was assessed 12 days after the …
(NMDA) receptor antagonist MK-801 and the L-type Ca2+ channel blocker nimodipine was
examined using an in vivo rat model of NMDA-induced neurodegeneration. Attention was
focused on the neuroprotective potential of this combined drug
treatmentbeforeandafterNMDA-exposure. NMDA was unilaterally injected in the
magnocellular nucleus basalis (MBN). Neuronal damage was assessed 12 days after the …
