Intra-hippocampal injection of NMDA (12.5 nmol) in postnatal day 7 (P7) rats results in
neuronal necrosis and hippocampal atrophy; injury extends into the adjacent striatum,
thalamus and cortex. NMDA-induced injury is marked by an acute microglial/monocyte
response; the molecular signals that control this response and the role of activated
microglia/monocytes in the progression of excitotoxic injury are unknown. Monocyte
chemoattractant protein-1 (MCP-1) is a well-characterized chemokine that regulates …