Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease
C Bjartmar, JR Wujek, BD Trapp - Journal of the neurological sciences, 2003 - Elsevier
Axonal degeneration has been identified as the major determinant of irreversible
neurological disability in patients with multiple sclerosis (MS). Axonal injury begins at
disease onset and correlates with the degree of inflammation within lesions, indicating that
inflammatory demyelination influences axon pathology during relapsing–remitting MS (RR-
MS). This axonal loss remains clinically silent for many years, and irreversible neurological
disability develops when a threshold of axonal loss is reached and compensatory CNS …
neurological disability in patients with multiple sclerosis (MS). Axonal injury begins at
disease onset and correlates with the degree of inflammation within lesions, indicating that
inflammatory demyelination influences axon pathology during relapsing–remitting MS (RR-
MS). This axonal loss remains clinically silent for many years, and irreversible neurological
disability develops when a threshold of axonal loss is reached and compensatory CNS …
