Functionalized fullerenes in water. The first 10 years of their chemistry, biology, and nanoscience

E Nakamura, H Isobe - Accounts of chemical research, 2003 - ACS Publications
E Nakamura, H Isobe
Accounts of chemical research, 2003ACS Publications
Fullerenes are entirely insoluble in water, but suitable functionalization makes the molecules
soluble. Studies on water-soluble fullerene derivatives led to the discovery of the interaction
of organofullerenes with DNA, proteins, and living cells, which was first reported in the
summer of 1993. Subsequent studies have revealed interesting biological activity aspects of
organofullerenes owing to their photochemistry, radical quenching, and hydrophobicity to
form one-to three-dimensional supramolecular complexes. In these areas of research …
Fullerenes are entirely insoluble in water, but suitable functionalization makes the molecules soluble. Studies on water-soluble fullerene derivatives led to the discovery of the interaction of organofullerenes with DNA, proteins, and living cells, which was first reported in the summer of 1993. Subsequent studies have revealed interesting biological activity aspects of organofullerenes owing to their photochemistry, radical quenching, and hydrophobicity to form one- to three-dimensional supramolecular complexes. In these areas of research, synthetic organic chemistry has played an important role in the creation of tailor-made molecules.
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