Linkage of a Cardiac Arrhythmia, the Long QT Syndrome, and the Harvey ras-1 Gene
M Keating, D Atkinson, C Dunn, K Timothy, GM Vincent… - Science, 1991 - science.org
M Keating, D Atkinson, C Dunn, K Timothy, GM Vincent, M Leppert
Science, 1991•science.orgGenetic factors contribute to heart disease. In this study, linkage analyses have been
performed in a family that is predisposed to sudden death from cardiac arrhythmias, the long
QT syndrome (LQT). A DNA marker at the Harvey ras-1 locus (H-ras-1) was linked to LQT
with a logarithm of the likelihood ratio for linkage (lod score) of 16.44 at θ= 0, which confirms
the genetic basis of this trait and localizes this gene to the short arm of chromosome 11. As
no recombination was observed between LQT and H-ras-1, and there is a physiological …
performed in a family that is predisposed to sudden death from cardiac arrhythmias, the long
QT syndrome (LQT). A DNA marker at the Harvey ras-1 locus (H-ras-1) was linked to LQT
with a logarithm of the likelihood ratio for linkage (lod score) of 16.44 at θ= 0, which confirms
the genetic basis of this trait and localizes this gene to the short arm of chromosome 11. As
no recombination was observed between LQT and H-ras-1, and there is a physiological …
Genetic factors contribute to heart disease. In this study, linkage analyses have been performed in a family that is predisposed to sudden death from cardiac arrhythmias, the long QT syndrome (LQT). A DNA marker at the Harvey ras-1 locus (H-ras-1) was linked to LQT with a logarithm of the likelihood ratio for linkage (lod score) of 16.44 at θ = 0, which confirms the genetic basis of this trait and localizes this gene to the short arm of chromosome 11. As no recombination was observed between LQT and H-ras-1, and there is a physiological rationale for its involvement in this disease, ras becomes a candidate for the disease locus.
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