Superoxide-mediated nitration of spinal manganese superoxide dismutase: a novel pathway in N-methyl-D-aspartate-mediated hyperalgesia
C Muscoli, V Mollace, J Wheatley, E Masini… - Pain, 2004 - Elsevier
N-methyl-d-aspartate (NMDA) receptors serve prominent roles in vast physio-pathological
conditions including hyperalgesia (defined as augmented pain intensity in response to
painful stimuli) associated with central sensitization. Using M40403 a synthetic low
molecular weight superoxide dismutase mimetic that removes superoxide we show for the
first time that this radical plays a key role in NMDA-mediated hyperalgesia. Intrathecal
administration of NMDA in rats led to a time-dependent development of thermal …
conditions including hyperalgesia (defined as augmented pain intensity in response to
painful stimuli) associated with central sensitization. Using M40403 a synthetic low
molecular weight superoxide dismutase mimetic that removes superoxide we show for the
first time that this radical plays a key role in NMDA-mediated hyperalgesia. Intrathecal
administration of NMDA in rats led to a time-dependent development of thermal …
